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Decreased AMH – Pregnancy rate
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Decreased AMH – Pregnancy rate

14 August 2011
|In FAQ
|By Gülden Halis

August 14, 2011

Prospects for success for women with extremely low AMH levels

Women with a severely reduced AMH level are occasionally excluded from fertility treatment or (prematurely) advised to donate eggs.

In the currently published work from a multicenter study (Vienna, New York, New Haven), the pregnancy rates (SR), abortion rates (AR), and live births (LG) of women with low AMH were examined. The women were on average 40.8 years old, had an average FSH value of 15.7 and an AMH value of 0.2 ng/ml. In 254 women, 254 IVF treatments were performed. All women began therapy after at least six weeks of DHEA pretreatment (as prescribed in the Fertility Practice in such cases is also routinely performed, according to D. Barad and N. Gleicher*) and subsequently received FSH-/FSH-LH stimulation therapy.

  • 20 pregnancies resulted (7.9% per cycle, 15.6% cumulative SSR).
  • Divided into age groups, 16 women aged <= 42 became pregnant (10 births/ 14.3%);,
    of those >42 years old 4 (2 births/ 3.4%).

The authors conclude that women with a significant reduction in AMH levels do have a low SSR, but fertility treatment should not be withheld from them prematurely.

However, literature research shows that achieving pregnancy at values below 0.15 ng/ml is extremely rare. There is only one published case of pregnancy in a woman with an AMH <0.1 ng/ml.

Source:
A. Weghofer, W. Dietrich, D. Barad, N. Gleicher: Live Birth Chances in women with extremely low-serum anti-Mullerian hormone levels - Human Reproduction, Vol. 26, No. 7

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