Pregnancy rate
Comparison of pregnancy rate with natural ovulation and HCG-induced ES in the cycle of insemination
08.03.2010
Comparison of pregnancy rate in natural ovulation (ES) and HCG-induced ES in the cycle. In a recent study published in “Fertility Sterility” 2010/ MedWire News (Human Mousavi Fatemi -Free University Brussels, Belgium), it was compared whether the pregnancy rate (SSR) in the cryo-embryotransfer cycle without hormonal stimulation, i.e., in the natural cycle, depends on whether the ovulation is triggered by a syringe (HCG) or it is left to the natural LH rise.
In 124 women in the natural cycle, the natural LH rise was awaited, and the embryo transfer was programmed for the 5th day thereafter (3 days of embryos each time). 63 women received HCG to trigger ovulation as soon as the follicle reached 17mm on ultrasound, after which it was also transferred on the 5th day.
In the group of women with a single spontaneous LH increase, the SSR was 31.1% (!!!), with an average ovulation trigger of 14.3% with HCG. In the women with ovulation trigger, an additional LH increase occurred at 36.5%. Of these, only 4.3% became pregnant. They concluded that this may lead to an impairment of implantation; that HCG and the natural LH, which are molecularly almost identical, interfere with each other at the receptor.
The investigators ended the study early because the difference was so pronounced.
Their study concluded that SSR (in cryo-ET) in the natural cycle with spontaneous ovulation is clearly superior to cycles triggered by HCG injection.
Source: Fertility and Sterility 2010; Advance online publication
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