Mini IVF™ and Vitrification
News 21.06.2010
A new approach proves its effectiveness
Mini IVF™ and Vitrification
In a soon-to-be-published study, the team led by Dr. John Zhang from the New Hope Fertility Center, New York, presents a controversial new approach in the context of the IVF present study. That the Mini IVF™ is a successful method and produces eggs and embryos is undoubtedly true. However, the fact that the endometrium (the uterine lining) sometimes suffers under the clomifene used in the procedure is also true. This is responsible for the lower pregnancy rate (SSR) compared to conventional IVF methods.
During the Mini IVF™ cycles conducted between January 2005 and December 2006, he allowed the embryos that reached the blastocyst stage to be frozen (vitrified), then thawed and transferred in one of the subsequent unstimulated/natural cycles. As is well known, the implantation quality of the uterine lining in the natural cycle is not only higher than in the Mini IVF™ cycle, but also when combined with a conventional cycle IVF.
Results:
In 202 women, a total of 249 FETs (Frozen Embryo Transfer) were performed. There were 88 small pregnancies (43.56 %%). On average, 1.86 embryos were transferred. Women with a low FSH value on the 3rd day of the cycle achieved a higher SSR than those with higher FSH.
| Age | < 35 | 35 -37 | 38 – 40 | 41 – 42 | 43 – 44 |
| Cycle number | 94 | 48 | 30 | 19 | 11 |
| FET/Patient | 1,1 | 1,4 | 1,2 | 1,2 | 1,2 |
| Embryo count/transfer | 1,7 | 1,7 | 2,2 | 1,8 | 2,8 |
| Klin. SSR | 54,3 | 45,8 | 30,0 | 21,1 | 9,1 |
This results in very high SSRs being achieved with the patient-friendly Mini IVF™ and subsequent vitrification.
Original work: Gentle ovarian stimulation in conjunction with elective vitrification of human embryos: a new approach for the practice of in-vitro fertilization
Authors: A. Nair, J. Zhang, S. Silber, A. Tran, N. Wugmeister, L. Chang
To be published soon in: Fertility Sterility 2010