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Chromosome defects
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Chromosome defects

10 December 2010
|In FAQ
|By Gülden Halis

December 10, 2010

Cause of embryonic chromosomal defects

After a publication of a research paper by various Dresden scientists in Current Biology (S.1529-1533) The age-related depletion of specific binding proteins causes chromosomal abnormalities in the eggs, which become increasingly common with age.

The chromosomes are held in place within the eggs by the so-called cohesins. During the woman’s maturation process, these binding proteins lose their binding force or are increasingly degraded. This explains the significant increase in chromosomal abnormalities in mature women, such as trisomy 21.

For example, at the age of 40, the rate of eggs with significant chromosomal abnormalities is 35 %.

From The Women's Doctor 51 (2010)

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